Genetics From Genes To Genomes 6th Edition Pdf Free Download

Dear Friend,

I’m excited to announce the release of my latest book, “Genetics from Genes to Genomes,” and I hope you will join me on the journey.

The book is a comprehensive guide to cellular biology, covering all aspects of how cells function. It’s written for anyone who wants to understand the underlying principles of biology that apply to cells in general. Given that this is my fourth book in this series, I’ve written this one with an eye for providing more specific information about the science. This book covers everything from cellular metabolism, genetic expression, and cell cycle control through to cell death, apoptosis, and stem cells, with a particular focus on how genes are transcribed and translated into mRNA (messenger RNA) and proteins.

I think it’s important to understand all these processes in order to be able to communicate effectively about them among students and expert alike. So I’ve included a lot of examples throughout the text that show how changes in one step can have a significant effect on another step. For example, we’ll talk about how the changes in DNA methylation can cause changes in gene expression that affect other steps in transcription and translation.

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About Genetics From Genes To Genomes 6th Edition Pdf Free Download

Genetics: From Genes to Genomes is a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. This edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between the early understanding of genetics and the new molecular discoveries that have changed the way the field of genetics is viewed.

Table of Content of Genetics From Genes To Genomes 6th Edition Pdf Free Download

Introduction: Genetics in the Twenty-First Century
Chapter 1
Genetics: The Study of Biological Information
1.1 DNA: Life’s Fundamental Information Molecule
1.2 Proteins: The Functional Molecules of Life Processes
1.3 Molecular Similarities of All Life-Forms
1.4 The Modular Construction of Genomes
1.5 Modern Genetic Techniques
1.6 Human Genetics and Society
Part I
Basic Principles: How Traits are Transmitted
Chapter 2
Mendel’s Principles of Heredity
2.1 The Puzzle of Inheritance
2.2 Genetics: Analysis According to Mendel
2.3 Mendelian Inheritance in Humans

  • – Genetics and Society: Developing Guidelines for Genetic Screening
    Chapter 3
    Extensions to Mendel’s Laws
    3.1 Extensions to Mendel for Single-Gene Inheritance
    3.2 Extensions to Mendel for Two-Gene Inheritance
    3.3 Extensions to Mendel for Multifactorial Inheritance
  • – Genetics and Society: Disease Prevention Versus the Right to Privacy
    Chapter 4
    The Chromosome Theory of Inheritance
    4.1 Chromosomes: The Carriers of Genes
    4.2 Sex Chromosomes and Sex Determination
    4.3 Mitosis: Cell Division That Preserves Chromosome Number
    4.4 Meiosis: Cell Divisions That Halve Chromosome Number
    4.5 Gametogenesis
    4.6 Validation of the Chromosome Theory
    4.7 Sex-Linked and Sexually Dimorphic Traits in Humans
  • – Genetics and Society: Prenatal Genetic Diagnosis
  • – Fast Forward: Transgenic Mice Prove That SRY Is the Maleness Factor
  • – Fast Forward: Visualizing X Chromosome Inactivation in Transgenic Mice
    Chapter 5
    Linkage, Recombination, and the Mapping of Genes on Chromosomes
    5.1. Gene Linkage and Recombination
    5.2 Recombination: A Result of Crossing-Over During Meiosis
    5.3 Mapping: Locating Genes Along a Chromosome
    5.4 The Chi-Square Test and Linkage Analysis
    5.5 Tetrad Analysis in Fungi
    5.6 Mitotic Recombination and Genetic Mosiacs
  • – Fast Forward: Mapping the Crossovers that Generate the Chromosomes of Individual
    Human Sperm
  • – Fast Forward: Gene Mapping May Lead to a Cure for Cystic Fibrosis
  • – Tools of Genetics: The Chi-Square Test for Goodness of Fit
  • – Genetics and Society: Mitotic Recombination and Cancer Formation
    Part II
    What Genes Are and What They Do
    Chapter 6
    DNA Structure, Replication, and Recombination
    6.1 Experimental Evidence for DNA as the Genetic Material
    6.2 The Watson and Crick Double Helix Model of DNA
    6.3 Genetic Information in Nucleotide Sequence
    6.4 DNA Replication
    6.5 Homologous Recombination at the DNA Level
    6.6 Site Specific Recombination
    Chapter 7
    Anatomy and Function of a Gene: Dissection Through Mutation
    7.1 Mutations: Primary Tools of Genetic Analysis
    7.2 Molecular Mechanisms That Alter DNA Sequence
    7.3 DNA Repair Mechanisms
    7.4 What Mutations Tell Us About Gene Structure
    7.5 What Mutations Tell Us About Gene Function
    7.6 A Comprehensive Example: Mutations That Affect Vision
  • – Fast Forward: Trinucleotide Repeat Diseases: Huntington Disease and Fragile X Syndrome
    Chapter 8
    Gene Expression: The Flow of Information from DNA to RNA to Protein
    8.1 The Genetic Code
    8.2 Transcription: From DNA to RNA
    8.3 Translation: From mRNA to Protein
    8.4 Differences in Gene Expressions Between Prokaryotes and Eukaryotes
    8.5 The Effects of Mutations on Gene Expression and Function
  • – Genetics and Society: HIV and Reverse Transcription
    Part III
    Analysis of Genetic Information
    Chapter 9
    Digital Analysis of DNA
    9.1 Fragmenting DNA
    9.2 Cloning DNA Fragments
    9.3 Sequencing DNA
    9.4 Sequencing Genomes
  • – Tools of Genetics: Serendipity in Science: The Discovery of Restriction Enzymes
    Chapter 10
    Genome Annotation
    10.1 Finding the Genes in Genomes
    10.2 Genome Architecture and Evolution
    10.3 Bioinformatics: Information Technology and Genomes
    10.4 A Comprehensive Example: The Hemoglobin Genes
    Chapter 11
    Analyzing Genomic Variation
    11.1 Variation Among Genomes
    11.2 Genotyping a Known Disease-Causing Mutation
    11.3 Samplilng DNA Variation in a Genome
    11.4 Positional Cloning
    11.5 The Era of Whole-Genome Sequencing
  • – Tools of Genetics: The Lod Score Statistic
    Part IV
    How Genes Travel on Chromosomes
    Chapter 12
    The Eukaryotic Chromosome
    12.1 Chromosomal DNA and Proteins
    12.2 Chromosome Structure and Compaction
    12.3 Chromosomal Packaging and Gene Expression
    12.4 Replication of Eukaryotic Chromosomes
    12.5 Chromosome Segregation
    12.6 Artificial Chromosomes
    Chapter 13
    Chromosomal Rearrangements and Changes in Chromosome Number
    13.1 Rearrangements of Chromosomal DNA
    13.2 The Effects of Rearrangements
    13.3 Transposable Genetic Elements
    13.4 Aberrations in Chromosome Number Aneuploidy
    13.5 Variation in Number of Chromosome Sets: Euploidy
    13.6 Genome Restructuring and Evolution
  • – Fast Forward: Programmed DNA Rearrangements and the Immune System
    Chapter 14
    Bacterial Genetics
    14.1 The Enormous Diversity of Bacteria
    14.2 Bacteria Genomes
    14.3 Bacteria as Experimental Organisms
    14.4 Gene Transfer in Bacteria
    14.5 Using Genetics to Study Bacterial Life
    14.6 A Compresensive Example: How N. gonorrhoeae Became Resistant to Penicillin
  • – Genetics and Society: The Human Microbiome Project
    Chapter 15
    Organellar Inheritance
    15.1 Mitochondria and Their Genomes
    15.2 Chloroplasts and Their Genomes
    15.3 The Relationship Between Organellar and Nuclear Genomes
    15.4 Non-Mendelian Inheritance of Mitochondria and Chloroplasts
    15.5 Mutant Mitochondria and Human Disease
  • – Genetics and Society: Mitochondrial DNA Tests as Evidence of Kinship in Argentine Courts
  • – Fast Forward: Mitochondrial Eve
    Part V
    How Genes are Regulated
    Chapter 16
    Gene Regulation in Prokaryotes
    16.1 The Elements of Prokaryotic Gene Expression
    16.2 Regulation of Transcription Initiation via DNA-Binding Proteins
    16.3 RNA-Mediated Mechanisms of Gene Regulation
    16.4 Discovering and Manipulating Bacterial Gene Regulatory Mechanisms
    16.5 A Comprehensive Example: Control of Bioluminescence by Quorum Sensing
    Chapter 17
    Gene Regulation in Eukaryotes
    17.1 Overview of Eukaryotic Gene Regulation
    17.2 Control of Transcription Initiation Through Enhancers
    17.3 Epigenetics
    17.4 Regulation After Transcription
    17.5 A Comprehensive Example: Sex Determination in Drosophila
  • – Tools of Genetics: The Gal4/UASg Binary Gene Expression System
    Part VI
    Using Genetics
    Chapter 18
    Manipulating the Genomes of Eukaryotes
    18.1 Creating Transgenic Organisms
    18.2 Uses of Transgenic Organisms
    18.3 Targeted Mutagenesis
    18.4 Human Gene Therapy
  • – Tools of Genetics: Cloning by Somatic Cell Nuclear Transfer
  • – Tools of Genetics: How Bacteria Vaccinate Themselves Agains Viral Infections with
    CRISPR/Cas9
  • – Genetics and Society: Should We Alter Human Germ-Line Genomes?
    Chapter 19
    The Genetic Analysis of Development
    19.1 Model Organisms: Prototypes for Developmental Genetics
    19.2 Mutagenesis Screens
    19.3 Determining Where and When Genes Act
    19.4 Ordering Genes in a Pathway
    19.5 A Comprehensive Example: Body Plan Development in Drosophila
    Chapter 20
    The Genetics of Cancer
    20.1 Characteristics of Cancer Cells
    20.2 The Genetic Basis of Cancers
    20.3 How Cell Division Is Normally Controlled
    20.4 How Mutations Cause Cancer Phenotypes
    20.5 Personalized Cancer Treatment
  • – Tools of Genetics: Analysis of Cell-Cycle Mutants in Yeast
    Part VII
    Beyond the Individual Gene and Genome
    Chapter 21
    Variation and Selection in Populations
    21.1 The Hardy-Weinberg Law: Predicting Genetic Variation in Ideal Populations
    21.2 What Causes Allele Frequencies to Change in Real Populations?
    21.3 Ancestry and the Evolution of Modern Humans
    Chapter 22
    The Genetics of Complex Traits
    22.1 Heritability: Genetic Versus Environmental Influences on Complex Traits
    22.2 Mapping Quantitative Trait Loci (QTLs)
  • – Tools of Genetics: The Chi-Square Test for Independence
    Guidelines for Gene Nomenclature
    Brief Answer Section
    Glossary
    Credits
    Index

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